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Using ECHO we analyze the most influential pathways, and performed in silico experiments to obtain insight into the molecular mechanisms of cartilage development and disease. PMID: Differentiation of mesenchymal stem cells under hypoxia and normoxia: lipid profiles revealed by time-of-flight secondary ion mass spectrometry and multivariate analysis. Kinases, a class of enzymes that can phosphorylate and thereby regulate target proteins, play a pivotal role in this intracellular signaling network and are responsible for integration of all signals into a specific cellular response. Because of its lubricating properties, it ensures the pain-free and supple movements of our joints. The complexity of the integrating signals severely constrain a complete and quantitative analysis of the precise signals that dictate cartilage maintenance. Biography Janine Post completed her PhD on signaling events regulating embryonic development and cancer at Memorial University of Newfoundland, Canada. Cartilage is mainly composed of one single cell type, the chondrocyte, that secretes and shapes the cartilaginous matrix that is necessary for its load-bearing properties.

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